bit-QED
Evolve
Custom bioinformatics and AI-driven enzyme discovery and enzyme and strain engineering for dramatic improvements in accuracy at decreased time and cost
Backed by a team of expert bioinformaticians, cheminformaticians, wet lab experts, and fermentation specialists, our unique computational platform finds, assays, and improves enzymes and pathways from bitBiome’s vast proprietary database to meet your precise needs.
Our enzyme mining process uses both sequence and structure-based target enzyme screening to identify a short list of highly-probable candidates in a matter of weeks. Enzymes are customised using in silico methods that employ structural modeling combined with machine learning and large language models. This identifies relevant amino acid substitutions that influence enzyme activity, help make beneficial changes to optimize activity, and subsequent high throughput screening of variants ensures that the changes had their intended effects. The process combines cycles of generating diverse mutants in silico followed by automated wet lab enzyme screening, getting smarter and more precise with each round.
Our programmable, automated, strain engineering platform is designed to maximize productivity to efficiently achieve commercial success. We rapidly predict and identify the best possible edits for custom metabolic rewiring, protein expression, and target ingredient production. Screening through collections of targeted edits creates the optimal strain for commercial scale-up. Combining our enzyme and pathway customization with targeted strain modification technologies, we routinely scale from discovery to commercial production, meaning bitBiome is your one-stop-shop partner for the entire biomanufacturing workflow.
Benefits
- Reduces a 2-3 year process to months or even weeks
- In silico and wet lab screening
- Skilled bioinformaticians and chemoinformaticians maximize conventional models and leverage proprietary ones
- Whole genome-wide strain engineering for optimized enzymes, pathways, and ingredients
By the Numbers
- >500x faster 3D structure analysis than Google AlphaFold2
- 24-hour bioinformatics results
- 75% reduction in time to enzyme result
- Up to 75% cost reduction compared to conventional methods
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To build a world beyond plastic, we first need to maximize the potential and performance of PETase enzymes.
