bit-MAP®
Sequence
The one and only single-cell sequencing technology for microbes that’s 100x more efficient than conventional methods
Single-cell sequencing is the only method that can provide in-depth functional and phylogenetic information.
Our patented technology uses microfluidics to capture and sequence individual bacterial genomes within isolated capsules. All biochemical reactions, including cell lysis and DNA amplification, take place within the capsule, eliminating conventional hurdles like isolation, culturing, and complex data processing. Our whole-genome reconstructions enable us to compare down to the sub-strain level, revealing not only genetic and functional information of individual bacteria, but also genetic differences between target and related strains.
Faster, cheaper, and vastly more accurate than typical microbe sequencing methods, bit-MAP powers massively parallel whole-genome sequencing and reduces the potential time for sequencing our planet’s microbe population from over 10,000 years to within a single generation.
Benefits
- Quantitative sequencing and analysis of microbial genomes at single-cell resolution
- Discovery of new species from unculturable and extremophile microbial samples
- Capable of sequencing difficult samples, including low biomass and high diversity samples
- Access to more detailed phylogenetic and functional information than 16S RNA
- Reveal strain heterogeneity and identify prebiotic responders, pathogens, and more
- Link mobile genetic elements and antibiotic resistance genes to their host microbes
- Highly diverse and most complete sequences of any method
- Longer contigs and gene clusters for more complete genomes than shotgun metagenomics
- Visibility into biosynthetic gene clusters
By the Numbers
- 100x more efficient gene analysis, including microbial dark matter, than shotgun metagenomics
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